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Journal and News Scan
The treatment approaches and in-hospital outcomes were analyzed for 885,806 patients with acute pulmonary embolism (PE) in Germany between 2005 and 2015. The incidence of acute PE increased from 85 per 100,000 in 2005 to 109 per 100,000 in 2015 [β 0.32 (0.26–0.38), P < 0.001]. During the same period, in-hospital case fatality rates decreased from 20.4% to 13.9% [β −0.51 (−0.52 to −0.49), P < 0.001]. The overall proportion of patients treated with systemic thrombolysis increased from 3.1% in 2005 to 4.4% in 2015 [β 0.28 (0.25–0.31), P < 0.001]. Thrombolysis was associated with lower in-hospital mortality rates in patients with hemodynamic instability, both in those with shock not necessitating cardiopulmonary resuscitation (CPR) or mechanical ventilation [odds ratio (OR) 0.42 (0.37–0.48), P < 0.001], and in patients who underwent CPR [OR 0.92 (0.87–0.97), P = 0.002]. This association was independent of age, sex, and comorbidities. However, systemic thrombolysis was administered to only 23.1% of hemodynamically unstable patients.
As the procedure began, doctors found that one lung was stuck to the chest bone forming bullae, which are like blisters and often occur with COPD. The surgeons punctured one of the blisters, causing an air leak. So that the patient wouldn't have trouble breathing, the anesthesiologist increased the amount of oxygen.
Fed by leaking oxygen, a spark from an electrocautery device set a dry surgical pack on fire. Doctors immediately put the fire out and continued with the procedure, successfully repairing the torn artery. The findings were presented at the 2019 European Society of Anesthesiology meeting in Vienna, Austria.
Left ventricular ejection fraction was not a predictor of outcomes after heart transplant, and was normal in all recipients at 1 year posttransplant. The reliance on generic transthoracic echocardiography for donor assessment may well be the Achilles heel of this retrospective case study.
The NEJM published the long-term results of the OVER study of open repair (OR) versus endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA) on May 30.
The OVER study demonstrated similar long-term overall survival between patients undergoing EVAR and OR. These results were not consistent with the findings of worse performance of EVAR with respect to long-term survival that were seen in two studies conducted in Europe.
In OVER, patients with asymptomatic AAA were randomly assigned to either EVAR or OR for aneurysm treatment and were followed for up to 14 years. This study enrolled 881 patients who were candidates for either procedure, with 444 assigned to EVAR and 437 to OR. The primary outcome was all-cause mortality. Although elective EVAR of AAA has shown lower perioperative mortality than OR, this survival advantage was not seen after 4 years.
Imporant trends include, although none were signficant:
- 302 patients (68%) in the EVAR group and 306 patients (70%) in the OR group died (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.82–1.13).
- In the first 4 years of follow-up, overall survival appeared to be higher with EVAR versus OR.
- In year 4 through year 8, overall survival was higher in the OR group.
- After 8 years, overall survival was higher in the EVAR group (HR for death, 0.94; 95% CI, 0.74–1.18).
- There were 12 aneurysm-related deaths (2.7%) in the EVAR group and 16 (3.7%) in the OR group (between-group difference, -1.0 percentage point; 95% CI, -3.3–1.4) with most deaths occurring in the perioperative period.
- Aneurysm rupture occurred in seven patients (1.6%) with EVAR, and rupture of a thoracic aneurysm occurred in one patient (0.2%) with OR (between-group difference, 1.3 percentage points; 95% CI, 0.1–2.6).
- Death from chronic obstructive lung disease was approximately 50% more common in OR patients than EVAR patients (8.2% vs 5.4%) with a between-group difference of -2.8 percentage points (95% CI, -6.2–0.5).
- More patients in the EVAR group underwent secondary procedures.
Tipograf and colleagues analyzed outcomes for 121 patients with end-stage lung disease who were placed on extracorporeal membrane oxygenation (ECMO), 70 of whom (59%) were successfully bridged to lung transplantation. Independent predictors of unsuccessful bridging included unplanned endotracheal intubation, renal replacement therapy, and cerebrovascular accident. Lung transplant recipients who received pretransplant ECMO support had similar outcomes to transplant recipients not receiving support, and the authors conclude that ECMO can be used successfully to bridge patients to lung transplantation when it is implemented by an experienced team with adherence to stringent protocols and patient selection.
Butt and colleagues examined the incidence and reasons for hospitalizations following coronary artery bypass grafting (CABG). This study was performed using a Danish nationwide registry including more than 30,000 patients. Within 1 year after CABG, 40% of patients were readmitted at least once, most of them due to a cardiovascular cause. Risk factors for readmission included lower socioeconomic status, preoperative comorbidities, postoperative complications during the index admission, and a longer length of stay in the hospital.
In this narrated video, Choe and Park present the case of a 56-year old woman with T3N0M0 lung cancer, who underwent robotic lobectomy with concomitant chest wall resection.
A common cause of donor lung unsuitability is aspiration pneumonitis. Pig lungs experimentally damaged by aspiration of gastric contents were supported using cross-circulation with a living swine donor, resulting in cellular regeneration and substantial recovery.
Using period hypercapnea as a surrogate "contrast" agent, myocardial oxygenation was assessed using cardiac MR and accurately mapped areas of relative ischemia.
Patient Care and General Interest
Despite being the leading cause of death in the US, heart disease was the most-Googled disease in only one state: Maine.
A study that sought to understand the importance of successful teamwork for general surgery used cardiothoracic surgical teams as their comparison group because of the stability and experience that these teams typically have.
Experts call attention to what they say is a public health crisis facing countries that continue to produce and use asbestos, including Brazil, Russia, India, and China.
A 50-year-old mitral valve prosthesis is rediscovered when a woman in Italy undergoes an operation.
Drugs and Devices
In an update to a letter sent in February 2019, the US Food and Drug Administration has warned healthcare providers against off-indication use of the Impella RP system from Abiomed, emphasizing that the benefits of the device outweigh the risks in appropriately selected patients.
Research, Trials, and Funding
Researchers from Pakistan and across the US report finding positive “spin” of results in approximately two-thirds of articles publishing cardiovascular-focused randomized clinical trials.
Metformin reduced left ventricular hypertrophy in patients with coronary artery disease who did not have diabetes, say researchers from the UK.
At the recent EuroPCR meeting in Paris, France, researchers present the usage of Abbott’s transcatheter tricuspid valve repair system to treat tricuspid regurgitation in 85 patients.
Canadian and Brazilian researchers report their use of radar to remotely monitor heart and respiratory rates, with 80% and 94% correlation with a wearable sensor, respectively.