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Journal and News Scan

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): David M. Kalfa, Elizabeth M. Cordoves, Vincent R. LaSala

Living allogeneic heart valve transplant (HVT) first emerged in 2022, featuring the unique advantage of being a valve capable of growth and self-repair over time, thus reducing the number of reoperations required in children undergoing valve intervention. This article summarizes the historical precedent for the use of growth-capable HVT, strategies for success, including the importance of preserving and implanting donor papillary musculature, and the reasons for long-term failure. Future research will focus on investigating the relationship between HVTs and donor-recipient size matching; acceptable warm and cold ischemic times, especially when papillary musculature is preserved; immunosuppression requirements; and the validation of current implantation protocols. 

Source: JAMA Network Open
Author(s): Justin Ren, Jason E. Bloom, William Chan, Christopher M. Reid, Julian A. Smith, Andrew Taylor, David Kaye, Colin Royse, David H. Tian, Andrea Bowyer, Doa El-Ansary, Alistair Royse

This retrospective cohort study evaluated the impact of preoperative ischemic heart failure with reduced ejection fraction on long-term outcomes following coronary revascularization using either single or multiple arterial grafting techniques. Data from 59,641 patients (mean age 65.8 years; 81 percent male) across 59 cardiac centers (2001–2020) were analyzed, with patients stratified by perioperative left ventricular ejection fraction (EF). Over a median follow-up of five years, multiarterial grafting was associated with a 19 percent reduction in all-cause mortality for those with normal EF (hazard ratio [HR]=0.81, P<0.001), and similar benefits were observed in patients with mild (HR=0.83), moderate (HR=0.82), and severe left ventricular (LV) impairment (HR=0.82, P=0.01). Cox regression analysis showed no significant interaction between survival benefit and EF (P=0.75). Total arterial revascularization provided additional survival benefits except in cases with EF less than 30 percent (HR=0.87, P=0.30). These findings support the consistent survival advantage of multiarterial grafting across LV function levels and advocate for the broader use of these strategies. 

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Parisa Rashidi, Arman Kilic, Adrienne Kline, Tom Liu, Patrick M. McCarthy, Douglas R. Johnston, Robert M. Sade

This article highlights the growing utility of artificial intelligence (AI) and machine learning (ML) in the field of cardiothoracic surgery and discusses the current and potential future ethical and legal implications, as well as concerns regarding impact on data privacy and the trust between patients and physicians. The article also emphasizes the opportunities and utility of AI in the preoperative and postoperative periods, including the use of segmentation algorithms to accurately measure aortic dimensions for the planning of transcatheter aortic valve implantation, as well as algorithms to model and predict the development of right heart failure after left ventricular assist device implantation. 

Source: Journal of Cardiothoracic Surgery
Author(s): Fangfang Yang, Lei Chen, Hui Wang, Qianyun Wang, Chen Yang

This retrospective analysis compared three-port and four-port robotic-assisted thoracoscopic surgery (RATS) lobectomy for non-small cell lung cancer (NSCLC)(n=121, 2020–2021). Demographics, tumor characteristics, complications, and lymph node yields were similar between groups. While the three-port group showed trends toward shorter operative time (117.32 vs. 136.83 minutes), console time (90 vs. 103 minutes), less blood loss (94.34 vs. 102.73 mL), shorter chest tube duration (2.43 vs. 2.79 days), and shorter hospital stay (4.55 vs. 5.14 days), these differences were not statistically significant (p>0.05). However, three-port patients reported significantly less postoperative pain. In line with the trend toward uniportal video-assisted thoracoscopic surgery (VATS), the authors propose that fewer ports in RATS may offer benefits, warranting further investigation. 

Source: The Annals of Thoracic Surgery
Author(s): Jiawei Chen, Ze-Rui Zhao, Hongsheng Deng, Chao Yang, Zhongqiao Mo, Lei Fan, Jianxing He, Shuben Li

Extended sleeve lobectomy (ESL) is considered a lung-sparing alternative to pneumonectomy (PN) for centrally located non-small cell lung cancer (NSCLC) when standard sleeve lobectomy (SSL) is not feasible. This retrospective study analyzed 94 patients who received neoadjuvant immunochemotherapy followed by either PN, ESL, or SSL. Patients undergoing ESL demonstrated lower predicted postoperative lung function compared to those who underwent PN. R0 resection rates were high across all groups, ranging from 94 to 98 percent, and postoperative complications were most frequent after PN (32.4 percent). Survival analysis showed no significant difference between ESL and SSL, but ESL offered longer event-free survival compared to PN. These findings indicate that ESL after neoadjuvant immunochemotherapy is a safe and effective option for selected patients, allowing for lung preservation without compromising oncologic outcomes, especially when SSL is insufficient for complete tumor removal. 

Source: European Heart Journal
Author(s): Didier Tchetche, Philippe Pibarot, Jeroen J Bax, Nikolaos Bonaros, Stephan Windecker, Nicolas Dumonteil, Fabian Nietlispach, David Messika-Zeitoun, Stuart J Pocock, Pierre Berthoumieu, Martin J Swaans, Leo Timmers, Tanja Katharina Rudolph, Sabine Bleiziffer, Lionel Leroux, Thomas Modine, Frank van der Kley, Vincent Auffret, Jacques Tomasi, Lukas Stastny, Christian Hengstenberg, Martin Andreas, Florence Leclercq, Thomas Gandet, Julia Mascherbauer, Karola Trescher, Bernard Prendergast, Mariuca Vasa-Nicotera, Alaide Chieffo, Jan Mares, Wilbert Wesselink, Radka Rakova, Jana Kurucova, Peter Bramlage, Helene Eltchaninoff

Women with severe symptomatic aortic stenosis are underrepresented in clinical trials. The Randomized Research in Women All Comers with Aortic Stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) compared to surgery in women. Women were randomized 1:1 to received either transfemoral TAVI with a balloon-expandable valve or surgical intervention. The primary composite endpoint was defined as death, stroke, or rehospitalization related to the valve, procedure, or heart failure within one year. Non-inferiority testing was conducted using a prespecified margin of 6 percent, alongside superiority testing in the as-treated population. 
 
At 48 European centers, 443 women were randomized, with 420 receiving treatment as randomized. The mean age of participants was 73 years, and the mean estimated surgical risk of death was 2.1 percent, as determined by the Society of Thoracic Surgeons risk score. Kaplan–Meier estimates of the primary endpoint event rates at one year were 8.9 percent in the TAVI group and 15.6 percent in the surgery group. This difference of −6.8 percent, with an upper 95 percent confidence limit of −1.5 percent, demonstrated the non-inferiority of TAVI (P < 0.001). The two-sided 95 percent confidence interval of −13.0 percent to −0.5 percent further resulted in superiority (P = 0.034). The one-year incidence of the primary endpoint components was as follows: 0.9 percent for TAVI vs. 2.0 percent for surgery for death from any cause; 3.3 percent vs. 3.0 percent for stroke; and 5.8 percent vs. 11.4 percent for rehospitalization. 
 
The authors concluded that among women with severe aortic stenosis, the incidence of the composite of death, stroke, or rehospitalization at one year was lower in the TAVI group compared to the surgery group. 

Source: Journal of Thoracic Oncology
Author(s): Akira Hamada, Junichi Soh, Akito Hata, Kiyoshi Nakamatsu, Mototsugu Shimokawa, Yasushi Yatabe, Jun Suzuki, Masahiro Tsubo, Akira Hamada, Junichi Soh, Akito Hata, Kiyoshi Nakamatsu, Mototsugu Shimokawa, Yasushi Yatabe, Jun Suzuki, Masahiro Tsuboi, Hidehito Horinouchi, Yuichi Sakairi, Masayuki Tanahashi, Shinichi Toyooka, Morihito Okada, Natusmi Matsuura, Hisayuki Shigematsu, Yasumasa Nishimura, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Tetsuya Mitsudomi

The recent CheckMate 816 trial indicated that neoadjuvant chemo-immunotherapy provided limited local control in stage II–III resectable non-small cell lung cancer (NSCLC). This trial evaluated the hypothesis that incorporating radiotherapy into the treatment plan—involving carboplatin and paclitaxel chemotherapy with neoadjuvant and adjuvant durvalumab—would lead to improved outcomes. 
 
Among 31 patients treated, the major pathologic response (MPR) rate was 63 percent, surpassing the primary endpoint, with a pathologic complete response (pCR) rate of 23 percent. At a median follow-up of 28 months, the two-year progression-free and overall survival rates were 43 percent and 76 percent, respectively. Grade 3 or 4 adverse events occurred in 48 percent of patients, including one treatment-related death. 
 
While this regimen achieved a higher MPR compared to recent perioperative chemo-immunotherapy trials, this did not translate into improved progression-free or overall survival outcomes. 

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Irbaz Hameed, Sriharsha Talapaneni, Lauren M. Barron, Yihan Lin, Brian Mitzman, Olugbenga T. Okusanya, Gavitt A. Woodard, Clauden Louis, Dina Al Rameni, J. Hunter Mehaffey, Kirsten A. Freeman, Xiaoying Lou, Andrew P. Dhanasopon, Sara Pereira, Cherie Erkmen, Lars G. Svensson

This article addresses the challenges of transitioning from cardiothoracic training to becoming a practicing cardiothoracic surgeon. It discusses the role of additional training in the form of “super-fellowships,” the selection of job opportunities, techniques for building a successful practice, strategies for becoming a productive researcher, and how to transition into a senior career role. This article provides insight from experienced surgeons, as well as advice and strategies to make this transition easier. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Néstor J Martínez-Hernández, Míriam Estors-Guerrero, José M Galbis-Caravajal, David Hervás-Marín, Amparo Roig-Bataller

This study analyzed long-term risk factors for compensatory sweating following bilateral endoscopic thoracic sympathectomy (BETS) in 98 patients between 2010 and 2023. Compensatory sweating as a side effect was classified as mild, moderate, or severe using the STS guidelines, while quality of life (QOL) was assessed via the Hyperhidrosis Disease Severity Scale. Logistic and Bayesian regression models were used to identify predictors of compensatory sweating. 
 
Overall, the procedure achieved a success rate of 94.38 percent, with 34.69 percent of patients reporting compensatory sweating, mostly mild (26.53 percent). Nearly all patients achieved significant reduction in sweating (≥50 percent in 97.95 percent; ≥80 percent in 94.89 percent). 
 
Protective factors highlighted were high hemoglobin levels and marijuana use. Conversely, tobacco smoking and the presence of combined hand-axillary hyperhidrosis increased the risk of compensatory sweating. Identifying at-risk patients, such as those who smoke tobacco and those with low hemoglobin levels, can help improve outcomes by managing expectations when undergoing (BETS). 

Source: Journal of the American College of Cardiology
Author(s): John K. Forrest, Steven J. Yakubov, G. Michael Deeb, Hemal Gada, Mubashir A. Mumtaz, Basel Ramlawi, Tanvir Bajwa, John Crouch, William Merhi, Stephane Leung Wai Sang, Neal S. Kleiman, George Petrossian, Newell B. Robinson, Paul Sorajja, Ayman Iskander, Pierre Berthoumieu, Didier Tchétché, Christopher Feindel, Eric M. Horlick, Shigeru Saito, Jae K. Oh, Yoojin Jung, Michael J. Reardon

The Evolut Low Risk trial demonstrated that transcatheter aortic valve replacement (TAVR) was noninferior to surgery for the primary endpoint of all-cause mortality or disabling stroke at two years. In this new publication, the authors report the five-year outcomes of the Evolut Low Risk trial. In this trial, low-risk patients with severe aortic stenosis were randomly assigned to TAVR or surgery. The primary endpoint was a composite of all-cause mortality or disabling stroke. Secondary endpoints included clinical, echocardiographic, and quality-of-life outcomes through five years. 
 
A total of 1,414 patients underwent attempted valve implantation (n = 730 for TAVR, n = 684 for surgery). The mean age was 74 years (range 51-88 years), and women accounted for 35 percent of the patients. At five years, the Kaplan-Meier estimate for the primary endpoint of all-cause mortality or disabling stroke was 15.5 percent for the TAVR group and 16.4 percent for the surgery group (P = 0.47). The Kaplan-Meier estimates in the TAVR and surgery groups for all-cause mortality were 13.5 percent and 14.9 percent (P = 0.39) and for disabling stroke were 3.6 percent and 4.0 percent (P = 0.57). Cardiovascular mortality was 7.2 percent in the TAVR group and 9.3 percent in the surgery group (P = 0.15). Noncardiovascular mortality in the TAVR group was 6.8 percent and 6.2 percent in the surgery group (P = 0.73). A site-level vital status sweep was performed for patients who were lost to follow-up or withdrew from the study. With the addition of these patients, the all-cause mortality rate at five years for patients undergoing TAVR was 14.7 percent, and for surgery, it was 15.2 percent (P = 0.74). Over five years, the valve reintervention rate was 3.3 percent for TAVR and 2.5 percent for surgery (P = 0.44). A sustained improvement in quality of life was observed in both treatment arms, with a mean Kansas City Cardiomyopathy Questionnaire summary score of 88.3 plus or minus 15.8 in TAVR and 88.5 plus or minus 15.8 in surgery. 

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