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Journal and News Scan

Source: Eur Heart J
Author(s): Usman Baber, Michael E. Farkouh, Yaron Arbel, Paul Muntner, George Dangas, Michael J. Mack, Taye H. Hamza, Roxana Mehran, Valentin Fuster

In the FREEDOM trial, 1900 diabetic patients were randomized between coronary bypass surgery and percutaneous coronary intervention (PCI). Of these, 451 patients had chronic kidney disease (CKD) with a GFR 30-60 mL/min/1.73m2, and the remaining patients were categorized as having no CKD. In both groups, bypass surgery performed better over 5-year follow-up than PCI in patients with CKD (26.0% versus 35.6%; HR=0.73, 95% CI 0.50-1.05) and no CKD (16.2% verus 23.6%; HR=0.76, 95% CI 0.58-1.00). Therefore, independent of chronic kidney disease, diabetic patients with multivessel disease should undergo CABG.

Source: Annals of Thoracic Surgery
Author(s): Timothy S Lancaster, Matthew R Schill, Jason W Greenberg, Marc R Moon, Richard B Schuessler, Ralph J Damiano, and Spencer J Melby

In this single institution retrospective study of postoperative cardiac surgery patients, serum potassium and magnesium levels at times when postoperative atrial fibrillation (POAF) occured were compared with levels in patients who did not experience POAF.  The incidence of POAF was 37%, and was associated with increasing magnesium levels.  Prophylactic potassium administration had no effect on POAF, whereas prophylactic magnesium administration was associated with an increase in POAF risk.

Source: Annals of Thoracic Surgery
Author(s): Byung Kwon Chong, Jae Suk Baek, Yu-Mi Im Im, Chun Soo Park, Jeong-Jun Park, and Tae-Jin Yun

This retrospective study evaluated whether a systemic-PA shunt in infants with TOF facilitated enlargement of the pulmonary valve annulus (PVA).  Placement of a shunt was the only factor associated with PVA growth.  This knowledge may affect how repair is staged with an eye towards avoiding a transannular patch.

Source: Annals of Thoracic Surgery
Author(s): Valerie W Rusch, Ritu R Gill, Alan Mitchell, David Naidich, David C Rice, Harvy I Pass, Hedy L Kindler, Marc De Perrot, and Joseph Friedberg

Semiautomated CT volumetric measurements of tumor volume in patients with malignant pleural mesothelioma were compared to stage and overall survival.  CT volumes correlated well with stage and survival.

Source: Annals of Thoracic Surgery
Author(s): Vinod H Thourani, Jessica Forcillo, Nirat Beohar, Darshan Doshi, Rupa Parvataneni, Girma M Ayele, Ajay J Kirtane, Vasilis Babaliaros, Susheel K Kodali, Chandan Devireddy, Wilson Y Szeto, Howard C Herrmann, Raj Makkar, Gorav Ailawadi, Scott Lim, Hersh S. Maniar, Alan Zajarias, Rakesh M Suri, E. Murat Tuzcu, Samir Kapadia, Lars G. Svensson, Jose Condado, Hanna A Jensen, Michael J Mack, and Martin B Leon

This analysis of PARTNER data evaluated the impact of chronic kidney disease (CKD) on outcomes after TAVR.  Patients were grouped according to GFR as none/mild, moderate, and severe renal disease.  Severe disease was most common among women with diabetes.  Severe disease was associated with a 50% increase in 30-day mortality and 1-year cominbed mortality and all-cause rehospitalization.  Assessment of renal function may help risk stratify patients who are candidates for TAVR. 

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Umberto Benedetto, Mario Gaudino, Massimo Caputo, Robert F. Tranbaugh, Christopher Lau, Antonino Di Franco, Colin Ng, Leonard N. Girardi, Gianni D. Angelini

The authors conducted a meta-analysis of propensity-scored matched patients in published studies to assess outcomes of right internal mammary artery (RIMA) and radial artery (RA) as second conduits for CABG.  Eight studies included nearly 3000 matched pairs.  RITA was associated with better long-term survival and freedom from reoperation, but also was associated with an increased risk of sternal wound infection when pedicled harvest was conducted.  

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Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Luca Di Marco, Davide Pacini, Antonio Pantaleo, Alessandro Leone, Giuseppe Barberio, Giuseppe Marinelli, Roberto Di Bartolomeo

This single institution retrospective review assessed outcomes of AVR in patients with concomitant aortic root disease using a composite graft.  Early mortality was 5.3% and was related to advanced age, poor NYHA status, urgent operation, and associated MVR or CABG.  Late death was related to CRI, COPD, aortic dissection, CABG, and use of the Cabrol technique.  10-year survival was 66%.

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Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Robert J. Cerfolio, Kyle H. Cichos, Benjamin Wei, Douglas J. Minnich

The success of training techniques including dividing robotic lobectomy into graduated steps, reviewing video peformances of trainees, and coaching through challenging technical maneuvers were tracked during a 5-year experience.  Performance of individual steps among general surgery and cardiothoracic surgery trainees increased over time, while metrics of outcomes remained the same or improved.

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Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Jessie Mei Lim, Theodore Kingdom, Brahmdeep Saini, Vann Chau, Martin Post, Susan Blaser, Christopher Macgowan, Steven P. Miller, Mike Seed

MRI assessment of cerebral blood flow and calculated cerebral oxygen delivery were compared between neonates with congenital heart disease and normal controls.   Although cerebral blood flow was similar between the groups, oxygen delivery was over 30% lower in neonates with congenital heart disease, primarily because of arterial desaturation.  These findings may influence the timing of repair of congenital heart disease.

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Source: Carcinogenesis
Author(s): Flores RM, Liu B, Taioli E

The authors assessed the relationship between second hand smoke exposure in non-smokers and mortality related to lung cancer using serum cotinine levels.  Cotinine levels were associated with survival, death from lung cancer, and death from all cancers after adjustment.  Such levels identify second hand smoke effects.