ALERT!
This site is not optimized for Internet Explorer 8 (or older).
Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.
Journal and News Scan
This single-center prospective trial evaluated same-day discharge (SDD) following subxiphoid thoracoscopic thymectomy in 39 patients with thymic tumors. The SDD completion rate was 92.3percent, with all patients achieving R0 resection. The perioperative complication rate was 5.6 percent, and only one patient required readmission within 30 days due to pneumothorax. The median hospital stay was just 11 hours, with median medical costs amounting to 19,400 renminbi (approximately EU €2,400). These findings suggest that SDD may be safe and feasible for selected patients undergoing this procedure, although larger studies are needed for confirmation.
The use of mechanical support devices in the pediatric population is an area of active investigation. The authors evaluated all pediatric patients at a single institution who presented in cardiogenic shock and were treated with an Impella device. A total of six patients were observed, who received Impella 2.5, Impella CP, and Impella 5.5, with a median duration of support of seven days (range: 4-45 days). Of these, two patients were bridged to recovery, three to left ventricular assist device (LVAD), and one to heart transplant. Given the absence of mortality or neurological complications, the authors suggest that use the of the Impella device is safe and feasible in this patient population.
Safety and Feasibility of Novel Single-Port Robotic-Assisted Lobectomy/Segmentectomy for Lung Cancer
This study evaluated the SHURUI single-port (SP) robotic system for uniportal robotic-assisted thoracic surgery (RATS) in lung cancer patients. Unlike conventional multi-incision systems, the SHURUI SP utilizes a single, highly flexible robotic arm, aiming to improve maneuverability and minimize incision size, which is especially beneficial for patients with limited thoracic space. In a phase I/II trial, 35 patients (median age 58) underwent lobectomy or segmentectomy. All surgeries were completed successfully, with no need to switch to other surgical methods or make additional incisions. The median operative time was 155 minutes, with minimal blood loss and no transfusions required. The 30-day complication rate was low at 11.43 percent, with no major issues or readmissions, and patients were typically discharged after four days. Compared to the multiple fully jointed arms required for the da Vinci single-port, the SHURUI SP provides a potential single-port alternative.
This article discusses a promising diagnostic approach aimed at improving patient selection for immune checkpoint inhibitor (ICI) therapies, particularly in non-small cell lung cancer (NSCLC). The current reliance on PD-L1 immunohistochemistry (IHC) as a biomarker has limited sensitivity and specificity. The concept of "touching" refers to the direct molecular interaction between PD-1 and PD-L1 proteins, which can be detected through proximity-based assays such as proximity ligation assay (PLA), Förster resonance energy transfer (FRET), and quantitative immunofluorescence (QIF). The authors highlight new evidence showing that higher PD-1/PD-L1 proximity scores—measured using second-generation PLA—correlate with better treatment responses and survival in ICI-treated patients with NSCLC.
This article is important to the cardiothoracic surgery and thoracic oncology communities, including CTSNet’s global audience, as it signals a potential paradigm shift in how surgical candidates for immunotherapy are selected. As immunotherapy becomes increasingly integrated into multimodal treatment, improved predictive biomarkers such as proximity assays could enhance personalized treatment strategies.
This study investigated the long-term outcomes of hardware removal (HR) in patients who had previously undergone surgical fixation for blunt chest trauma, with a median of 11.5 rib fractures stabilized per patient. A retrospective review spanning 2017 to 2023 was performed, with follow-up assessments conducted approximately 28 months after HR. The study focused on improvements in mobility, self-care, daily activities, mental health, and symptoms such as chest pain and tightness. Among 28 patients, HR was primarily performed due to persistent pain, discomfort, chest tightness, hardware dislocation, or infection, usually around 18 months after the initial surgery. Surgeons employed a muscle-sparing technique through the previous incision, with or without excision. Patients experiencing chest tightness and infections reported the greatest symptom relief, with 75 percent showing improvement, followed by those with hardware dislocation. All patients in these groups expressed full satisfaction and a willingness to undergo HR again if needed.
This article reviews recent efforts to evaluate the use of osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), in the neoadjuvant setting for patients with resectable EGFR-mutant non-small cell lung cancer (NSCLC). While adjuvant osimertinib has shown benefits in delaying recurrence, as shown in the ADAURA trial, its effectiveness as a neoadjuvant monotherapy remains under evaluation. The NORA trial, along with the NEOS trial and a U.S.-based study, showed good tolerability and universal R0 resection rates; however, the objective response rates (ORRs) and low pathologic response were modest, especially in patients with nodal disease.
This editorial discusses how these findings suggest that neoadjuvant osimertinib may be insufficient as monotherapy, particularly when compared to immunotherapy-based combinations used in EGFR-wildtype disease. It calls for future trials to refine patient selection, explore combination strategies (e.g., with chemotherapy), and validate surrogate endpoints such as ctDNA clearance or residual viable tumor.
These insights are highly relevant to the CTSNet community, as it informs surgical planning and the integration of targeted therapies in the evolving landscape of personalized lung cancer treatment.
This study analyzed pregnancy outcomes in female lung transplant (LuT) recipients, focusing on modifiable factors that could improve outcomes. Using data from the Transplant Pregnancy Registry International (TPRI), the study included 53 women who reported 72 pregnancies after LuT between 1991 and 2021. Most transplants were performed due to cystic fibrosis or pulmonary hypertension. Notably, only 36 percent of participants used contraception post-transplant, and 54 percent of the pregnancies were unplanned. The live birth rate was 62 percent; however, 60 percent of babies were premature and of low birth weight. Birth defects were reported in 16 percent of cases, but none were linked to mycophenolic acid usage.
Unplanned pregnancies were associated with lower maternal survival and poorer newborn outcomes, including lower gestational age and birth weight. In contrast, planned pregnancies resulted in healthier babies and better maternal survival. These findings highlight that effective pregnancy planning is the most important modifiable factor for improving outcomes for both mothers and their children after lung transplantation.
This article studied the use of both surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) in patients with low-flow, low-gradient aortic stenosis, including both classical and paradoxical variants of the condition. A total of 131 patients (52 percent) underwent SAVR, while 117 patients (47 percent) underwent TAVR. The outcomes showed comparable results in terms of 20-day mortality, stroke, and the need for pacemaker, suggesting similarities between the two techniques.
This article investigated the role of different definitions of warm ischemia time during donation after circulatory death (DCD) heart transplants and the development of severe primary graft dysfunction (PGD). The authors found that prolonged donor hypoxia before normothermic regional perfusion (NRP)—specifically, more than 23 minutes in patients with a functional warm ischemic time defined by oxygen saturation below 80 percent—was associated with significantly higher rates of severe PGD. Interestingly, the authors also identified a linear association suggesting that elevated PGD rates correlated with increased ischemia time. Other outcomes, such as overall mortality and length of hospital stay, were not significantly different.
The question of whether minimal invasive extracorporeal circulation (MiECC) represents the optimal perfusion strategy in cardiac surgery remains unanswered. The authors aimed to systematically review the entire literature and thoroughly address the impact of MiECC vs conventional cardiopulmonary bypass (cCPB) on adverse clinical outcomes after cardiac surgery. Major databases, including PubMed, Scopus, and Cochrane, were searched for relevant articles as well as conference proceedings from major congresses up to August 31, 2024. All randomized controlled trials (RCTs) that fulfilled universally accepted MiECC criteria were included in the analysis. The primary outcome was mortality, while morbidity and transfusion requirements were secondary outcomes. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. All studies that met the outcomes of interest of this systematic review were eligible for synthesis. Of the 738 records identified, 36 RCTs were included in the meta-analysis, with a total of 4,849 patients. MiECC was associated with significantly reduced mortality (OR 0.66; 95 percent CI: 0.53-0.81; p=0.0002; I2=0 percent) as well as risk of postoperative myocardial infarction (OR 0.42; 95 percent CI: 0.26-0.68; p=0.002; I2=0 percent) and cerebrovascular events (OR 0.55; 95 percent CI: 0.37-0.80; p=0.007; I2=0 percent). Additionally, MiECC reduced RBC transfusion requirements, blood loss, and the rate of reexploration for bleeding, along with the incidence of atrial fibrillation. This resulted in significantly reduced durations of mechanical ventilation, ICU, and hospital stay.
This is the largest meta-analysis published to date, providing robust evidence for the beneficial effect of MiECC in reducing postoperative morbidity and mortality after cardiac surgery and prompts for a wider adoption of this technology.