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Journal and News Scan

Source: Vascular
Author(s): Jesse Chait, Pavel Kibrik, Ahmad Alsheekh, Natalie Marks, Sareh Rajaee, Anil Hingorani, Enrico Ascher

Descending thoracic endovascular aneurysm repair (D-TEVAR) is often performed by vascular surgeons. At many institutions, cardiothoracic surgery support is required for an elective TEVAR to take place. Oftentimes, this means a dedicated cardiopulmonary bypass team must be available.

In this study, the vascular team from NYU Langone Hospital in Brooklyn, New York, retrospectively analyzed their experience in 18 patients who underwent D-TEVAR between March 2014 and January 2018. No major complications occurred. Two patients experienced a type II endoleak. No patients required conversion to an open procedure, nor did any patients necessitate intervention by cardiothoracic surgery or cardiopulmonary bypass support.

Although these data suggest that cardiothoracic surgery support is not required D-TEVAR, the conclusion should be interpreted very cautiously. The importance of multidisciplinary collaboration in treating patients with aortic disease cannot be overemphasized.

Source: Journal of the American College of Cardiology
Author(s): Damini Dey, Piotr J. Slomka, Paul Leeson, Dorin Comaniciu, Sirish Shrestha, Partho P. Sengupta, Thomas H. Marwick

This review summarizes recent promising applications of artificial intelligence (AI) in cardiology and cardiac imaging, which potentially add value to patient care.

Problems with timing, efficiency, and missed diagnoses occur at all stages of the imaging chain. The application of AI may reduce cost and improve value at all stages of image acquisition, interpretation, and decision-making. The main fields of AI for imaging will pertain to disease phenotyping, diagnostic support, and image interpretation. Grouping of relevant clinical and imaging information with cluster analysis may provide opportunities to better characterize disease. Diagnostic support will be provided by automated image segmentation and automated measurements. The initial steps are being taken towards automated image acquisition and analysis. “Big data” from imaging will interface with high volumes of data from the electronic health record and pathology to provide new insights and opportunities to personalize therapy.

Source: The New England Journal of Medicine
Author(s): Jeffrey J. Popma, G. Michael Deeb, Steven J. Yakubov, Mubashir Mumtaz, Hemal Gada, Daniel O’Hair, Tanvir Bajwa, John C. Heiser, William Merhi, Neal S. Kleiman, Judah Askew, Paul Sorajja, Joshua Rovin, Stanley J. Chetcuti, David H. Adams, Paul S. Teirstein, George L. Zorn III, John K. Forrest, Didier Tchétché, Jon Resar, Antony Walton, Nicolo Piazza, Basel Ramlawi, Newell Robinson, George Petrossian, Thomas G. Gleason, Jae K. Oh, Michael J. Boulware, Hongyan Qiao, Andrew S. Mugglin, Michael J. Reardon, for the Evolut Low Risk Trial Investigators

A number of interesting findings in early follow up of this randomized controlled trial on one type of transcatheter aortic valve against conventional surgery: the mechanics of the valve and the incidence of complete heart block, to name but a few. We await the longer follow up.

Source: Journal of the American College of Cardiology
Author(s): WRITING COMMITTEE MEMBERS, Donna K. Arnett, Roger S. Blumenthal, Michelle A. Albert, Erin D. Michos, Andrew B. Buroker, Michael D. Miedema, Zachary D. Goldberger, Daniel Muñoz, Ellen J. Hahn, Sidney C. Smith, Cheryl D. Himmelfarb, Salim S. Virani, Amit Khera, Kim A. Williams, Sr., Donald Lloyd-Jones, Joseph Yeboah, J. William McEvoy, Boback Ziaeian, ACC/AHA TASK FORCE MEMBERS, Patrick T. O’Gara, Joshua A. Beckman, Glenn N. Levine, Sana M. Al-Khatib, Mark A. Hlatky, Kim K. Birtcher, John Ikonomidis, Joaquin E. Cigarroa, José A. Joglar, Anita Deswal, Laura Mauri, Lee A. Fleisher, Mariann R. Piano, Federico Gentile, Barbara Riegel, Zachary D. Goldberger, Duminda N. Wijeysundera

The American College of Cardiology's 68th Annual Scientific Session has released the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. This guideline includes newly generated recommendations for control of blood presssure, cholesterol and type II diabetes, aspirin use, regular exercise and physical activity, heathier diet, and tobacco use, in addition to recommendations related to team-based care, shared decision-making, and assessment of social determinants of health, to create a comprehensive yet targeted ACC/AHA guideline on the prevention of atherosclertoic cardiovascular disease.

Source: JAMA Surgery
Author(s): Amelia W. Maiga, Stephen A. Deppen, Jason Denton, Michael E. Matheny, Erin A. Gillaspie, Jonathan C. Nesbitt, Eric L. Grogan

The institution-specific uptake of VATS for lung cancer resection in the US Veterans Affairs system was evaluated over the past 15 years. Uptake more than tripled during the study period, with a current mean of more than 50% among institutions. However, uptake ranged from 0 to 82% and was associated with increasing center volume.

Source: News from around the web.
Author(s): Claire Vernon

Drugs and Devices

The US Food and Drug Administration (FDA) announced that the indications for the MitraClip™, made by Abbott, have been expanded to include secondary mitral regurgitation.

Saranas, Inc, announced that it’s Early Bird Bleed Monitoring System for detecting bleeding events during endovascular procedures was granted de novo classification by the US FDA.

European regulators offered decisions on immunotherapies for treating advanced lung cancer, with Roche’s atezolizumab and Merck’s pembrolizumab receiving approvals for expanded indications from the European Commission, and Pfizer’s lorlatinib being endorsed by the European Medicines Agency’s drug review panel.


Research, Trials, and Funding

An educational initiative that provided cardiac surgeons with information on their transfusion rates reduced blood utilization without affecting quality measures, a finding that was presented at the recent American College of Cardiology’s Cardiovascular Summit in Orlando, Florida.

Researchers in Japan report that the number of operations performed for complex congenital heart disease in Japan increased following the 2011 earthquake and nuclear accident in Fukushima.

Cardiac MRI shows promise for predicting allograft rejection in heart transplant recipients, say researchers from Chicago, Illinois, USA.

Source: Journal of Experimental Medicine
Author(s): Moises Freitas-Andrade, Nan Wang, John F. Bechberger, Marijke De Bock, Paul D. Lampe, Luc Leybaert, Christian C. Naus

Researchers from the University of British Columbia, Seattle and Belgium successfully used a new approach that significantly minimized brain damage caused by ischemic stroke in mouse models. The new approach works by blocking hemichannels—pathways allowing for the flow of chemical ions and small molecules—that are expressed by astrocytes, ie, cells playing a protective role for neurons in the brain.

The hypothesis is that when stroke occurs, these hemichannels open and leak toxic molecules into the space outside the astrocytes, causing inflammation and damage to neurons; therefore, blockade of these channels may minimize damage to the brain during stroke.

In this study, a genetic approach that mutated the channel proteins, called Connexin-43 (Cx43), was used to block the formation of hemichannels. This allows the astrocytes to protect the neurons, significantly reducing the size of the stroke injury in the brain. Pharmacological blockade of Cx43 hemichannels with a molecule called TAT-Gap19 in the same ischemic stroke model, also resulted in smaller stroke damage.

These two approaches demonstrate that Connexin hemichannel blockers could be used as a neuroprotective agent in stroke. Thus, a new treatment of ischemic stroke may soon be possible. 

Connexin hemichannel blockers also have a potential role in treating other neurodegenerative conditions such as traumatic brain injury and Alzheimer's disease.

Source: Circulation Research
Author(s): Sebastian Brandhorst, Valter D. Longo

Very useful open access review, especially the simple figure on page 959.

Source: The American College of Cardiology Press Releases
Author(s): The American College of Cardiology

On Wednesday March 13, the ACC Quality Summit announced in New Orleans that beginning in mid-2019, hospitals performing transcatheter valve repair and replacement will be able to apply for the American College of Cardiology's new Transcatheter Valve Certification.

The ACC's Transcatheter Valve Certification is an external review and certification process that will hold hospitals to specific standards for multidisciplinary teams, formalized training and shared decision-making. Participation in a national clinical registries such as the Trancathether Valve Therapy (TVT) registry is required for certification. The TVT registry tracks patient characteristics, procedural indications, and outcomes for patients undergoing transcatheter aortic valve replacement and transcatheter mitral valve repair.

According to the release, the certification will link process improvements to patient outcomes and will be “responsive to the resourcing at hospitals focused and committed to performance improvement in patient care delivery and coordination post-procedure.” Participation in the program will also connect hospitals to data which can track performance metrics and inform best practices.

Source: The New York Times
Author(s): Anahad O’Connor

Dr Eric Topol, a cardiologist and founder and director of the Scripps Research Translational Institute, has long heralded the use of artificial intelligence in medicine and healthcare. Now, in his new book “Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again,” Dr Topol explores how artificial intelligence is likely to transform almost everything that doctors do.