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Journal and News Scan

Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Bardia Arabkhani, Jos A. Bekkers, Eleni-Rosalina Andrinopoulou, Jolien W. Roos-Hesselink, Johanna J. M. Takkenberg, and Ad J. J. C. Bogers
A single institution experience is reported for outcomes of aortic allograft use in 353 pts undergoing 92 subcoronary and 261 root replacements.  Hospital mortality was 5.9%.  Mean follow-up was 12 years, during which time 113 pts died.  20-year survival was 41%.  117 pts required valve-related reoperations.  Long-term mortality was related to LV dilatation and severe AR.
Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Michele Murzi, Alfredo Giuseppe Cerillo, Danyar Gilmanov, Giovanni Concistrè, Pierandrea Farneti, Mattia Glauber, Marco Solinas
Early single institution experience with minimally invasive sutureless aortic valve replacement was reported.  Among 300 patients, surgeon-specific and institution-specific learning curves were evaluated for technical success and 30-day complications.  A cluster of complications occurred early in the experience and then standardized.  No significant learning curve was identified for technical success, although 3 of 6 surgeons exhibited a brief initial learning curve for this metric. 
Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Aristine Cheng, Hsin-Yun Sun, Mao-Song Tsai, Wen-Je Ko, Pi-Ru Tsai, Fu-Chang Hu, Yee-Chun Chen, Shan-Chwen Chang
An institutional registry of ECMO patients was surveyed to determine predictors of survival among patients receiving ECMO in the presence of sepsis.  Among 151 studied patients, pneumonia was the most common cause of sepsis.  Mortality was predicted by advanced age, longer door-to ECMO times, gram-negative sepsis, and sepsis due to infections other than pneumonia.
Source: Journal of Thoracic and Cardiovascular Surgery
Author(s): Jiaquan Zhu, James Meza, Atsuko Kato, Arezou Saedi, Devin Chetan, Rachel Parker, Christopher A. Caldarone, Brian W. McCrindle, Glen S. Van Arsdell, Osami Honjo
In this single institution retrospective study, the relationship of PA pressure to long-term mortality was assessed in patients undergoing unifocalization for pulmonary atresia with VSD.  A mean PA intraoperative pressure > 25mm Hg was associated with worse survival, and was the sole predictor of medium-term death.
Source: European Journal of Cardiothoracic Surgery
Author(s): Doose C, Kütting M, Egron S, Farhadi Ghalati P, Schmitz C, Utzenrath M, Sedaghat A, Fujita B, Schmitz-Rode T, Ensminger S, Steinseifer U.
Valve in valve transcatheter aortic valve implantation (ViV-TAVI) is an alternative to redo surgical aortic valve replacement (SAVR) in inoperable patients and inpatients at high operative risk. This has become even more important now that approximately 80% of all SAVR are bioprostheses and bioprostheses are implanted at younger age. Several TAVI valves have received CE mark and premarket approval for use in degenerated bioprosthesis. This study analysed the effects of design of four different surgical bioprostheses on the hydrodynamic function of an Edwards Sapien XT valve implanted as a ViV-TAVI.   Main findings of this study were: Although there was complete coaptation of the leaflets in all 23-mm label-size ViV combinations, there were considerable differences in regurgitation measurements. This means the differences are attributable to paravalvular leakage. The Sapien XT in the Trifecta and the Perimount had the largest paravalvular leakage compared to the Aspire and Mosaic valves. The paravalvular leakages are most likely the result of different valve material as the porcine leaflets of the Aspire and the Mosaic are less stiff and provide better seal. Surgical valves with externally mounted leaflets (Trifecta) have an increased risk of paravalvular leakage in the ViV combination. On the other hand, mean pressure gradient (MPG) was lower in valves with a higher surgical inner diameter (the Perimount and Trifecta valves). Higher MPG was the result of underexpansion of the Sapien XT in the Trifecta and Mosaic valves, leading to axial overlap of the leaflets. In conclusion: This study showed that surgical valves with a large valve area improved hemodynamics for future ViV-TAVI combinations. Moreover, internally mounted leaflets seem to decrease the risk of paravalvular leakage.  Although this is an interesting study, this bench test study was limited to 23mm surgical valves and no calcifications or pannus of the surgical valves were simulated. Use of the valve-in-valve app developed by Dr. Bapat, remains helpful for clinicians making decisions on which TAVI valve is recommended in a specific surgical valve (   
Source: Annals of Thoracic Surgery
Author(s): Emanuela Taioli, Philip Kent Paschal, Bian Liu, Andrew J Kaufman, Raja M. Flores
This systematic review of the literature evaluated reported outcomes of myasthenia gravis in patients with and without thymectomy.  Among over 10,000 patients evenly divided between thymectomy and medication alone, the likelihood of remission was 31% vs 15%, OR 2.44. 
Source: Annals of Thoracic Surgery
Author(s): Vladimiro L. Vida, Chiara Tessari, Biagio Castaldi, Massimo A. Padalino, Ornella Milanesi, Dario Gregori, Giovanni Stellin
A single institution experience during 22 years for early repair of complete AV canal defects (CAVCD) is reported.  Repair was performed in 159 pts between 8 and 12 weeks of age.   Operative mortality was 1.9% and later mortality was 7.7%.  13% required reoperation during long-term follow-up, primarily for left AV valve regurgitation.  Left AV valve performance at last follow-up was significantly worse in pts older than 3 mons when repaired.
Source: Annals of Thoracic Surgery
Author(s): Lucas Goense, Peter S.N. van Rossum, Jelle P. Ruurda, Marco van Vulpen, Stella Mook, Gert J. Meijer, Richard van Hillegersberg
This retrospective single institution study evaluated the relationship between radiation dose to the gastric fundus and the incidence of esophageal anastomotic leak after esophagectomy for cancer.  The leak rate was 26%.  Pts with a leak had a significantly higher RT dose to the gastric fundus.  Using a cut point of 31.4 Gy, leak rates were 43% vs 15% for the high and low dose radiation exposure.  Radiation dose was an independent predictor of anastomotic leak in multivariable analysis.
Source: Annals of Thoracic Surgery
Author(s): Suvitesh Luthra, Miguel M. Leiva Juárez, Eshan Senanayake, Heyman Luckraz, John S. Billing, James Cotton, Michael S. Norell
In this  retrospective study of propensity-matched patients undergoing CABG, the authors queried whether prior PCI adversely affected outcomes.  9% of over 4500 pts undergoing first time CABG had prior PCI.  There was no difference between the groups with regard to hospital mortality or 10-year survival. 
Source: Journal of Thoracic Oncology
Author(s): Pamela Samson, Clifford Robinson, Jeffrey Bradley, A. Craig Lockhart, Varun Puri, Stephen Broderick, Daniel Kreisel, A. Sasha Krupnick, G. Alexander Patterson, Bryan Meyers, Traves Crabtree
The authors queried the NCDB to compare outcomes for patients undergoing induction chemotherapy vs chemoradiotherapy followed by resection for esophageal cancer.  The vast majority received chemoradiotherapy (87.5%), which was associated with a better pCR rate and a lower positive margin rate than chemotherapy.   30 and 90-day mortality rates were similar.  In spite of this, there was no difference in overall survival between the groups.