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Journal and News Scan
A multidisciplinary panel of lung cancer experts, facilitated by the European Society of Thoracic Surgeons and the European Respiratory Society, developed practical recommendations for assessing patients’ fitness for curative intent treatments for lung cancer by formulating four population, intervention, comparison and outcomes (PICO) questions and seven complementary narrative questions. The panel utilized systematic literature search and risk assessment tools to evaluate the evidence and created recommendations covering pulmonary function tests, split lung function values, exercise tests, cardiologic testing, and the role of prehabilitation, sublobar resections, risk scores and comorbidities in patient selection.
This 10-year, single-center, propensity-matched study compared the outcomes of resident-led operations with those of consultant-led operations at a high-volume UK center. This study investigated index adult cardiac surgical procedures as defined in the UK training curriculum, specifically isolated coronary artery bypass grafting (CABG), isolated aortic valve replacement (AVR), and combined CABG and AVR. Of a total of 11,372 such procedures performed between 2015 and 2024, propensity matching yielded 4,259 pairs for analysis (n = 8,518).
Despite longer cardiopulmonary bypass and aortic cross-clamp times in resident-led cases, the groups had a higher incidence of deep sternal wound infection (1.2 percent vs 0.7 percent, p = 0.033) and a one-day longer median hospital stay (seven vs six days, p < 0.001). However, they exhibited comparable in-hospital mortality and rates of other postoperative complications, as well as comparable long-term survival extending to 10 years. Subgroup analyses demonstrated comparable morbidity, mortality, and long-term survival across each index procedure type.
These findings provide reassurance for current cardiac surgical training models, indicating that a supervised, stepwise increase in residents’ operative responsibility can be implemented safely despite persistent scrutiny of outcomes and ongoing constraints on training time and operative exposure. By focusing on curriculum-defined index procedures, the study supports the safe incorporation of progressive operative autonomy within structured training programs without adversely affecting patient outcomes.
This systematic review and meta-analysis evaluated whether preprocedural fasting reduces the risk of witnessed pulmonary aspiration. Across 2,105 patients, aspiration was rare and not influenced by liberal vs restrictive fasting regimens (odds ratio 1.17, 95 percent CI 0.32–4.23). Trial sequential analysis indicated that further studies are unlikely to change this conclusion. Most prior evidence supporting fasting relied on surrogate outcomes such as gastric volume and pH, which have never been shown to correlate with clinical aspiration. The authors conclude that there is no evidence linking liberal fasting to aspiration and suggest that fasting policies could be liberalized, potentially guided by bedside gastric ultrasound.
In this article from the British Medical Journal, the author examines AI-generated images of doctors using OpenAI’s ChatGPT, comparing these depictions with real-world medical workforce data. A total of 24 images were generated, with eight images each for NHS, UK, and US doctors across different specialties. The results showed that only 25 percent of the generated images depicted female doctors, with women appearing in specialties such as obstetrics and pediatrics. In terms of ethnicity, 75 percent of US doctors were shown as white. Notably, images generated with the NHS prompt predominantly featured ethnic minority doctors, while those with the UK prompt depicted white doctors.
A meta-analysis of nine studies involving 8,557 patients found that early chest tube removal after cardiac surgery was associated with a higher risk of pericardial effusion, although it resulted in shorter hospital stays without significant differences in mortality or postoperative infections. The findings suggest that while early removal may be safe in terms of mortality and infections, it should be approached with caution and monitored closely for potential complications.
This novel study examined tricuspid annular (TA) remodeling in conscious, awake sheep with functional tricuspid regurgitation (FTR) using tachycardia-induced cardiomyopathy. Fifteen sheep underwent thoracotomy with sonomicrometry crystal implantation around the TA and right ventricular epicardium. Eight surviving animals had baseline measurements acquired while awake, then underwent pacing (180-240 bpm for 18±2 days) until developing FTR. The model produced moderate-severe FTR, with a 48 percent increase in right ventricular (RV) volume, a 57 percent enlargement of the TA area, and a 24 percent perimeter expansion. Critically, all annular segments dilated significantly: the anterior perimeter increased by 27 percent, the posterior perimeter increased by 17 percent, and the septal perimeter by 25 percent (all p<0.01), with the TA area contraction decreasing from 16.6 percent to 4.5 percent. The authors conclude that septal annular dilation, which has traditionally been unsupported by partial rings, may explain high annuloplasty failure rates, suggesting that complete annular support could improve surgical durability in severe FTR.
In this propensity score matched analysis of 1,531 patients undergoing mitral valve surgery, women presented at an older age, with more advanced symptoms and more complex valve pathology than men. Female patients more frequently exhibited Carpentier type IIIA disease, annular calcification, and concomitant tricuspid involvement, resulting in lower rates of mitral valve repair and minimally invasive surgery. Women experienced higher mortality rates at 30 days and five years. However, after adjusting for valve morphology, calcification, and surgical strategy, sex was no longer an independent predictor of repair rates or long-term survival. These findings indicate that adverse outcomes in women are primarily driven by delayed referrals and more complex disease rather than sex itself, highlighting the need for earlier recognition and intervention.
This study from the Mini-Mitral International Registry (2015-2021) compared endo-aortic balloon occlusion (EABO) to transthoracic clamping (TTC) in minimally invasive mitral valve surgery. After propensity matching 733 pairs from 6,884 patients, EABO showed significantly lower rates of conversion to sternotomy, although it was associated with longer cardiopulmonary and intubation times. Mortality, stroke, bleeding, vascular complications, ICU stay, and hospital length were similar between the groups. The authors concluded that both techniques are excellent options, but EABO reduces sternotomy conversion rates.
This retrospective analysis of the UNOS registry investigated patients after the latest allocation revision and examined whether ex vivo heart perfusion (EVHP) mitigated ischemic penalties in adult donation-after-brain-death heart transplants with preservation times of six hours or more. Among 546 recipients who met the criteria (320 receiving EVHP and 226 undergoing static/hypothermic storage), EVHP was associated with superior one-year survival (92.5 percent vs 86.3 percent, p=0.029) and three-year survival (90.9 percent vs 79.6 percent, p<0.001). Multivariable Cox regression confirmed that EVHP reduced the risk of mortality (HR 1.90 for non-EVHP, 95 percent CI 1.08-3.35, p=0.027), with benefits concentrated at high-volume centers. Spline analyses demonstrated an increase in mortality with prolonged preservation in static storage, attenuated by EVHP. The authors conclude that EVHP offsets the survival penalty associated with ischemic times of six hours or more, potentially enabling safer long-distance procurement and broader donor utilization.
Alessandro Tamburrini, a consultant thoracic surgeon, reflects on how Professor Peter Altman saved his life as a child with an advanced pelvic rhabdomyosarcoma through innovative treatment and surgery. Inspired by Altman’s compassion and expertise, Tamburrini dedicated his career to medicine, aiming to pay forward the second chance he received.